dna damage repair markers Search Results


dna damage  (TargetMol)
92
TargetMol dna damage
Chemical screen of <t>DNA</t> <t>damage</t> response inhibitors in KRAS mutant lung cancer cell. (A) Representative Western blot results. VE822 is a known ATR inhibitor. (B) Screening results. Each dot represents one compound. The value represents pCHK1/CHK1 ratio normalized to that of CPT only and are presented in log2 scale. Zero represents that of CPT. (C) A549 cells were pre-, co- or 1 h post-treated with 500 nM AT2, AT3 or TP4 with 500 nM CPT for 4 h, and protein levels of pCHK1 and CHK1 were analyzed. Ponceau S staining indicates equal protein loading. (D) A549 cells were pre-treated with 500 nM AT2 for 2 h, added 500 nM CPT for 1, 2 and 8 h, and levels of pCHK1 and CHK1 were examined. (E) A549 cells were pre-treated with different concentrations of AT2 for 2 h, added 500 nM CPT for another 4 h, and protein expression was examined using indicated antibodies. Lower: levels of pCHK1 normalized to total CHK1 from 5 independent experiments were used to determine the IC50 of AT2. (F) A549 cells were transfected with siRNA control or targeting the α1 subunit of Na/K-ATPase for 48 h, treated with 500 nM AT2 for 2 h, added 200 nM CPT for another 4 h, and protein expression was examined. Relative pCHK1 levels are shown above.
Dna Damage, supplied by TargetMol, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dna damage/product/TargetMol
Average 92 stars, based on 1 article reviews
dna damage - by Bioz Stars, 2026-03
92/100 stars
  Buy from Supplier
dna damage repair  (Selleck Chemicals)
91
Selleck Chemicals dna damage repair
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Dna Damage Repair, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dna damage repair/product/Selleck Chemicals
Average 91 stars, based on 1 article reviews
dna damage repair - by Bioz Stars, 2026-03
91/100 stars
  Buy from Supplier
ge array q series human dna damage and repair signaling pathway cdna expression array membranes  (SuperArray Bioscience Corporation)
90
SuperArray Bioscience Corporation ge array q series human dna damage and repair signaling pathway cdna expression array membranes
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Ge Array Q Series Human Dna Damage And Repair Signaling Pathway Cdna Expression Array Membranes, supplied by SuperArray Bioscience Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ge array q series human dna damage and repair signaling pathway cdna expression array membranes/product/SuperArray Bioscience Corporation
Average 90 stars, based on 1 article reviews
ge array q series human dna damage and repair signaling pathway cdna expression array membranes - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
free-radical-induced dna damage and its repair  (Verlag GmbH)
90
Verlag GmbH free-radical-induced dna damage and its repair
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Free Radical Induced Dna Damage And Its Repair, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/free-radical-induced dna damage and its repair/product/Verlag GmbH
Average 90 stars, based on 1 article reviews
free-radical-induced dna damage and its repair - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
dna damage repair (ddr) score  (Immunome Inc)
90
Immunome Inc dna damage repair (ddr) score
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Dna Damage Repair (Ddr) Score, supplied by Immunome Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dna damage repair (ddr) score/product/Immunome Inc
Average 90 stars, based on 1 article reviews
dna damage repair (ddr) score - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
transcription-coupled repair of oxidative dna damage  (Abbott Laboratories)
90
Abbott Laboratories transcription-coupled repair of oxidative dna damage
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Transcription Coupled Repair Of Oxidative Dna Damage, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/transcription-coupled repair of oxidative dna damage/product/Abbott Laboratories
Average 90 stars, based on 1 article reviews
transcription-coupled repair of oxidative dna damage - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
free-radical induced dna damage and its repair: a chemical perspective  (Verlag GmbH)
90
Verlag GmbH free-radical induced dna damage and its repair: a chemical perspective
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Free Radical Induced Dna Damage And Its Repair: A Chemical Perspective, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/free-radical induced dna damage and its repair: a chemical perspective/product/Verlag GmbH
Average 90 stars, based on 1 article reviews
free-radical induced dna damage and its repair: a chemical perspective - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
mutational status and loh determination for genes involved in dna damage and repair  (Myriad Genetics)
90
Myriad Genetics mutational status and loh determination for genes involved in dna damage and repair
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Mutational Status And Loh Determination For Genes Involved In Dna Damage And Repair, supplied by Myriad Genetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mutational status and loh determination for genes involved in dna damage and repair/product/Myriad Genetics
Average 90 stars, based on 1 article reviews
mutational status and loh determination for genes involved in dna damage and repair - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
p53 dna-damage markers  (MyBiosource Biotechnology)
90
MyBiosource Biotechnology p53 dna-damage markers
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
P53 Dna Damage Markers, supplied by MyBiosource Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/p53 dna-damage markers/product/MyBiosource Biotechnology
Average 90 stars, based on 1 article reviews
p53 dna-damage markers - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
dna damage repair panel  (Invitae Inc)
90
Invitae Inc dna damage repair panel
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Dna Damage Repair Panel, supplied by Invitae Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dna damage repair panel/product/Invitae Inc
Average 90 stars, based on 1 article reviews
dna damage repair panel - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
dna damage repair (ddr) network  (Hao Wen Holdings)
90
Hao Wen Holdings dna damage repair (ddr) network
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Dna Damage Repair (Ddr) Network, supplied by Hao Wen Holdings, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dna damage repair (ddr) network/product/Hao Wen Holdings
Average 90 stars, based on 1 article reviews
dna damage repair (ddr) network - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
dna damage markers  (Bydgoszcz)
90
Bydgoszcz dna damage markers
Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to <t>DNA</t> <t>damage</t> reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-
Dna Damage Markers, supplied by Bydgoszcz, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dna damage markers/product/Bydgoszcz
Average 90 stars, based on 1 article reviews
dna damage markers - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


Chemical screen of DNA damage response inhibitors in KRAS mutant lung cancer cell. (A) Representative Western blot results. VE822 is a known ATR inhibitor. (B) Screening results. Each dot represents one compound. The value represents pCHK1/CHK1 ratio normalized to that of CPT only and are presented in log2 scale. Zero represents that of CPT. (C) A549 cells were pre-, co- or 1 h post-treated with 500 nM AT2, AT3 or TP4 with 500 nM CPT for 4 h, and protein levels of pCHK1 and CHK1 were analyzed. Ponceau S staining indicates equal protein loading. (D) A549 cells were pre-treated with 500 nM AT2 for 2 h, added 500 nM CPT for 1, 2 and 8 h, and levels of pCHK1 and CHK1 were examined. (E) A549 cells were pre-treated with different concentrations of AT2 for 2 h, added 500 nM CPT for another 4 h, and protein expression was examined using indicated antibodies. Lower: levels of pCHK1 normalized to total CHK1 from 5 independent experiments were used to determine the IC50 of AT2. (F) A549 cells were transfected with siRNA control or targeting the α1 subunit of Na/K-ATPase for 48 h, treated with 500 nM AT2 for 2 h, added 200 nM CPT for another 4 h, and protein expression was examined. Relative pCHK1 levels are shown above.

Journal: Cancer letters

Article Title: Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy

doi: 10.1016/j.canlet.2020.08.008

Figure Lengend Snippet: Chemical screen of DNA damage response inhibitors in KRAS mutant lung cancer cell. (A) Representative Western blot results. VE822 is a known ATR inhibitor. (B) Screening results. Each dot represents one compound. The value represents pCHK1/CHK1 ratio normalized to that of CPT only and are presented in log2 scale. Zero represents that of CPT. (C) A549 cells were pre-, co- or 1 h post-treated with 500 nM AT2, AT3 or TP4 with 500 nM CPT for 4 h, and protein levels of pCHK1 and CHK1 were analyzed. Ponceau S staining indicates equal protein loading. (D) A549 cells were pre-treated with 500 nM AT2 for 2 h, added 500 nM CPT for 1, 2 and 8 h, and levels of pCHK1 and CHK1 were examined. (E) A549 cells were pre-treated with different concentrations of AT2 for 2 h, added 500 nM CPT for another 4 h, and protein expression was examined using indicated antibodies. Lower: levels of pCHK1 normalized to total CHK1 from 5 independent experiments were used to determine the IC50 of AT2. (F) A549 cells were transfected with siRNA control or targeting the α1 subunit of Na/K-ATPase for 48 h, treated with 500 nM AT2 for 2 h, added 200 nM CPT for another 4 h, and protein expression was examined. Relative pCHK1 levels are shown above.

Article Snippet: Chemical library screen The chemical library contains 874 compounds from both the Institute of Traditional Chinese Medicine and the DNA damage and repair library from TargetMol (#L3900) ( Supplementary Table S1 ).

Techniques: Mutagenesis, Western Blot, Staining, Expressing, Transfection

Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to DNA damage reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-

Journal: Molecular oncology

Article Title: PTEN-mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells.

doi: 10.1002/1878-0261.13563

Figure Lengend Snippet: Fig. 7. Blocking PTEN SUMOylation pathway sensitizes tumor cells to DNA damage reagents. (A–C) DU145-PTEN/ and PTENWT cells were treated with or without different doses of Cisplatin for 3 days, Zeocin for 2 days or CPT for 2 days and then cultured for another 7– 10 days. Colony number was counted and presented as bar graph. (D) DU145-PTEN/, PTENWT, PTENK254R and PTENK266R cells were trea- ted with or without TAK981 (100 nM) for 3 days and cultured for another 7–10 days. Total intensity of stained colony was measured by IMA-

Article Snippet: Ni2+-NTA pull down for SUMOylation assay For the detection of PTEN SUMOylation during DNA damage repair, 293T cells were transfected with His-SUMO1 and indicated plasmids for 48 h. CPT (#S1288, Selleck, Houston, TX, USA) and Zeocin (#60216ES80, Yeasen) were used to induce DNA damage for 1 h. cells were harvested at indicated time, 10% cells were used as input.

Techniques: Blocking Assay, Cell Culture, Staining